The HIV-associated tuberculosis epidemic--when will we act?
Identifieur interne : 004514 ( Main/Exploration ); précédent : 004513; suivant : 004515The HIV-associated tuberculosis epidemic--when will we act?
Auteurs : Anthony D. Harries [France] ; Rony Zachariah ; Elizabeth L. Corbett ; Stephen D. Lawn ; Ezio T. Santos-Filho ; Rhehab Chimzizi ; Mark Harrington ; Dermot Maher ; Brian G. Williams ; Kevin M. De CockSource :
- Lancet (London, England) [ 1474-547X ] ; 2010.
Descripteurs français
- KwdFr :
- Afrique subsaharienne (épidémiologie), Anti-infectieux (usage thérapeutique), Antirétroviraux (usage thérapeutique), Antituberculeux (usage thérapeutique), Association triméthoprime-sulfaméthoxazole (usage thérapeutique), Besoins et demandes de services de santé, Flambées de maladies, Humains, Infections opportunistes liées au SIDA (), Infections opportunistes liées au SIDA (diagnostic), Infections opportunistes liées au SIDA (traitement médicamenteux), Infections opportunistes liées au SIDA (épidémiologie), Infections à VIH (diagnostic), Infections à VIH (traitement médicamenteux), Infections à VIH (épidémiologie), Isoniazide (usage thérapeutique), Lutte contre l'infection, Programmes gouvernementaux, Santé mondiale, Tuberculose pulmonaire (), Tuberculose pulmonaire (diagnostic), Tuberculose pulmonaire (épidémiologie), Établissements de santé.
- MESH :
- diagnostic : Infections opportunistes liées au SIDA, Infections à VIH, Tuberculose pulmonaire.
- traitement médicamenteux : Infections opportunistes liées au SIDA, Infections à VIH.
- usage thérapeutique : Anti-infectieux, Antirétroviraux, Antituberculeux, Association triméthoprime-sulfaméthoxazole, Isoniazide.
- épidémiologie : Afrique subsaharienne, Infections opportunistes liées au SIDA, Infections à VIH, Tuberculose pulmonaire.
- Besoins et demandes de services de santé, Flambées de maladies, Humains, Infections opportunistes liées au SIDA, Lutte contre l'infection, Programmes gouvernementaux, Santé mondiale, Tuberculose pulmonaire, Établissements de santé.
English descriptors
- KwdEn :
- AIDS-Related Opportunistic Infections (diagnosis), AIDS-Related Opportunistic Infections (drug therapy), AIDS-Related Opportunistic Infections (epidemiology), AIDS-Related Opportunistic Infections (prevention & control), Africa South of the Sahara (epidemiology), Anti-Infective Agents (therapeutic use), Anti-Retroviral Agents (therapeutic use), Antitubercular Agents (therapeutic use), Disease Outbreaks, Global Health, Government Programs, HIV Infections (diagnosis), HIV Infections (drug therapy), HIV Infections (epidemiology), Health Facilities, Health Services Needs and Demand, Humans, Infection Control, Isoniazid (therapeutic use), Trimethoprim, Sulfamethoxazole Drug Combination (therapeutic use), Tuberculosis, Pulmonary (diagnosis), Tuberculosis, Pulmonary (epidemiology), Tuberculosis, Pulmonary (prevention & control), Tuberculosis, Pulmonary (therapy).
- MESH :
- chemical , therapeutic use : Anti-Infective Agents, Anti-Retroviral Agents, Antitubercular Agents, Isoniazid, Trimethoprim, Sulfamethoxazole Drug Combination.
- geographic , epidemiology : Africa South of the Sahara.
- diagnosis : AIDS-Related Opportunistic Infections, HIV Infections, Tuberculosis, Pulmonary.
- drug therapy : AIDS-Related Opportunistic Infections, HIV Infections.
- epidemiology : AIDS-Related Opportunistic Infections, HIV Infections, Tuberculosis, Pulmonary.
- prevention & control : AIDS-Related Opportunistic Infections, Tuberculosis, Pulmonary.
- therapy : Tuberculosis, Pulmonary.
- Disease Outbreaks, Global Health, Government Programs, Health Facilities, Health Services Needs and Demand, Humans, Infection Control.
Abstract
Despite policies, strategies, and guidelines, the epidemic of HIV-associated tuberculosis continues to rage, particularly in southern Africa. We focus our attention on the regions with the greatest burden of disease, especially sub-Saharan Africa, and concentrate on prevention of tuberculosis in people with HIV infection, a challenge that has been greatly neglected. We argue for a much more aggressive approach to early diagnosis and treatment of HIV infection in affected communities, and propose urgent assessment of frequent testing for HIV and early start of antiretroviral treatment (ART). This approach should result in short-term and long-term declines in tuberculosis incidence through individual immune reconstitution and reduced HIV transmission. Implementation of the 3Is policy (intensified tuberculosis case finding, infection control, and isoniazid preventive therapy) for prevention of HIV-associated tuberculosis, combined with earlier start of ART, will reduce the burden of tuberculosis in people with HIV infection and provide a safe clinical environment for delivery of ART. Some progress is being made in provision of HIV care to HIV-infected patients with tuberculosis, but too few receive co-trimoxazole prophylaxis and ART. We make practical recommendations about how to improve this situation. Early HIV diagnosis and treatment, the 3Is, and a comprehensive package of HIV care, in association with directly observed therapy, short-course (DOTS) for tuberculosis, form the basis of prevention and control of HIV-associated tuberculosis. This call to action recommends that both HIV and tuberculosis programmes exhort implementation of strategies that are known to be effective, and test innovative strategies that could work. The continuing HIV-associated tuberculosis epidemic needs bold but responsible action, without which the future will simply mirror the past.
DOI: 10.1016/S0140-6736(10)60409-6
PubMed: 20488516
Affiliations:
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santé</term><term>Flambées de maladies</term><term>Humains</term><term>Infections opportunistes liées au SIDA</term><term>Lutte contre l'infection</term><term>Programmes gouvernementaux</term><term>Santé mondiale</term><term>Tuberculose pulmonaire</term><term>Établissements de santé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite policies, strategies, and guidelines, the epidemic of HIV-associated tuberculosis continues to rage, particularly in southern Africa. We focus our attention on the regions with the greatest burden of disease, especially sub-Saharan Africa, and concentrate on prevention of tuberculosis in people with HIV infection, a challenge that has been greatly neglected. We argue for a much more aggressive approach to early diagnosis and treatment of HIV infection in affected communities, and propose urgent assessment of frequent testing for HIV and early start of antiretroviral treatment (ART). This approach should result in short-term and long-term declines in tuberculosis incidence through individual immune reconstitution and reduced HIV transmission. Implementation of the 3Is policy (intensified tuberculosis case finding, infection control, and isoniazid preventive therapy) for prevention of HIV-associated tuberculosis, combined with earlier start of ART, will reduce the burden of tuberculosis in people with HIV infection and provide a safe clinical environment for delivery of ART. Some progress is being made in provision of HIV care to HIV-infected patients with tuberculosis, but too few receive co-trimoxazole prophylaxis and ART. We make practical recommendations about how to improve this situation. Early HIV diagnosis and treatment, the 3Is, and a comprehensive package of HIV care, in association with directly observed therapy, short-course (DOTS) for tuberculosis, form the basis of prevention and control of HIV-associated tuberculosis. This call to action recommends that both HIV and tuberculosis programmes exhort implementation of strategies that are known to be effective, and test innovative strategies that could work. The continuing HIV-associated tuberculosis epidemic needs bold but responsible action, without which the future will simply mirror the past.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Chimzizi, Rhehab" sort="Chimzizi, Rhehab" uniqKey="Chimzizi R" first="Rhehab" last="Chimzizi">Rhehab Chimzizi</name><name sortKey="Corbett, Elizabeth L" sort="Corbett, Elizabeth L" uniqKey="Corbett E" first="Elizabeth L" last="Corbett">Elizabeth L. Corbett</name><name sortKey="De Cock, Kevin M" sort="De Cock, Kevin M" uniqKey="De Cock K" first="Kevin M" last="De Cock">Kevin M. De Cock</name><name sortKey="Harrington, Mark" sort="Harrington, Mark" uniqKey="Harrington M" first="Mark" last="Harrington">Mark Harrington</name><name sortKey="Lawn, Stephen D" sort="Lawn, Stephen D" uniqKey="Lawn S" first="Stephen D" last="Lawn">Stephen D. Lawn</name><name sortKey="Maher, Dermot" sort="Maher, Dermot" uniqKey="Maher D" first="Dermot" last="Maher">Dermot Maher</name><name sortKey="Santos Filho, Ezio T" sort="Santos Filho, Ezio T" uniqKey="Santos Filho E" first="Ezio T" last="Santos-Filho">Ezio T. Santos-Filho</name><name sortKey="Williams, Brian G" sort="Williams, Brian G" uniqKey="Williams B" first="Brian G" last="Williams">Brian G. Williams</name><name sortKey="Zachariah, Rony" sort="Zachariah, Rony" uniqKey="Zachariah R" first="Rony" last="Zachariah">Rony Zachariah</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Harries, Anthony D" sort="Harries, Anthony D" uniqKey="Harries A" first="Anthony D" last="Harries">Anthony D. Harries</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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